In: Goldman L, Schafer AI, eds. C peptide. Tissues with higher amounts of ALP include the liver, bile ducts, and bone. Intestinal strangulation or obstruction, or ulcerative lesion. They also can vary with age and sex. ALP is also secreted from the placenta during pregnancy. In that case you must use the respective reference tables. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at support@selfdecode.com. Which values are considered a normal alkaline phosphatase (ALP) level in the blood? Goldman-Cecil Medicine. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. In the statistical analysis the sample population is subdivided by sex and age, two variables which are known to influence enzyme activity. Information developed by A.D.A.M., Inc. regarding tests and test results may not directly correspond with information provided by UCSF Health. Pseudohyperparathyroidism. 1. Can Fatty Liver Disease Cause Sudden Death? The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. Its usually combined with other liver and kidney function tests. Explore our network of care for kids, from the tiniest to teens and young adults. Philadelphia, PA: Elsevier Saunders; 2016:chap 146. Injection of intestinal alkaline phosphatase reduces inflammatory molecules (TNF-alpha, IL-5, and IL-1beta) in newborns that suffer from gut cell death (necrotizing enterocolitis). Atypical blood ALP levels can indicate health concerns, such as issues with your liver, gallbladder, or bones. They also can vary with age and sex. Approach to the patient with jaundice or abnormal liver tests. Low ALP can also indicate a rare condition called hypophosphatasia. Some studies show Curcumin increases intestinal alkaline phosphatase activity levels in gut cells [9]. If you experience this complication, apply a warm compress until the swelling goes down. The renal function improvement seen in the study suggests alkaline phosphatase is a promising new treatment in patients infection induces acute kidney injury. We've got you covered. Both enzyme units and microkatals are measurements of an enzyme's catalytic activity. Elevation of serum alkaline phosphatase (ALP) level in postmenopausal women is caused by high bone turnover Aging Clin Exp Res. If ALP comes back high, the doctor may order the ALP isozyme test to see which specific type of alkaline phosphatase is elevated. . We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. No statistically significant influence of blood type on enzyme activity was observed. The normal range for children is higher than that for adults, especially for infants and teens because their bones are growing rapidly. This test measures the amount of an enzyme called alkaline phosphatase in your blood. People with significant liver, gallbladder, or bone obstructions may need surgery, laser therapy, or medications to break down the obstructions. Alkaline phosphatase (ALP) is an enzyme found in the blood that helps break down proteins. Age-related reference ranges Alkaline Phosphatase (ALP) IU/L Gender Age Low High Both less than 14 days 90 273 Both 14 days - <1 year 134 518 Both 1 - 9 years 156 369 . Bone cancer occurs when a tumor, or atypical mass of tissue, forms in a bone. Background: Transient hyperphosphatasemia (TH) is an often unnoticed benign entity, primarily affecting children below 5 years of age. 25th ed. Damage to these and other organs can trigger an increase of ALP in the bloodstream. Sharma U, et al. Hyperparathyroidism, in some patients. Most of the time blood is drawn from a vein located on the inside of the elbow or the back of the hand. An ALP test is a blood test. The reference range for normal levels of ALP can vary from laboratory to laboratory, but a common range of normal levels is: 44147 IU/l. Normal: 120/70 to 120/80 millimeters of mercury (mmHg). Your liver can regenerate and heal itself. An ALP test requires a blood sample from a vein. Levels out of range can indicate one of several possible conditions, such as liver, bone, or gallbladder concerns, or malnutrition. ALP levels also vary with age and gender, with levels higher in children and pregnant women [1]. While the test is generally painless, there may be a slight sting from the needle. Gilbert syndrome: Increase in intestinal alkaline phosphatase is seen.7. 3,4. The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. Checking ALP levels in the blood is a routine part of liver function and gallbladder tests. . Turn off your ad blocker to continue reading. Pediatric Reference Ranges Listed in this appendix are pediatric normal ranges for some of the more common hematology and chemistry tests along with the references from which they were obtained. Philadelphia:WB Saunders Company, 1999; 676-684. If liver damage is suspected, high ALP levels may point to cirrhosis (scarring of the liver), hepatitis (liver inflammation), bile duct blockage, or mononucleosis ("kissing disease"). Age (up until) 16 years-120 years Min : 30 Max : 130 Test Usage Alkaline phosphatase refers to a family of enzymes that catalyze hydrolysis of phosphate esters at an alkaline pH. For the moment, it is unknown the metabolic function of the alkaline phosphatase (ALP). Moss DW, Henderson RA. What is the alkaline phosphatase (ALP) blood test used for? Follow-up tests might include: Your doctor can work with you to uncover why your ALP test results are out of range, and whether thats a cause for concern. P2.5-P97 reference ranges for alkaline phosphatase in healthy boys. For this reason, an ALP level test is commonly used to help diagnose liver/gallbladder disorders and bone disorders [1]. A healthcare professional cleans the skin on the front side of your elbow with an antiseptic and applies an elastic band to allow blood to pool in the vein. Serum enzyme activities may reach 10 to 12 times the URV and usually return to baseline on surgical removal of the obstruction. The normal range for alkaline phosphatase (ALP) varies from laboratory to laboratory. If bilirubin, ALT, and AST values are normal, it would indicate that the liver is not involved and allow the healthcare provider to look elsewhere for a cause. It is recommended that only one assay method be used consistently to monitor each patient's course of therapy. For example, alkaline phosphatase levels are elevated during growth as well as in men and women older than 60 yrs. Is the ketogenic diet right for autoimmune conditions? Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Fatty metamorphosis of liver (moderate increase occurs in acute fatty liver). In Paget disease of bone there is often isolated elevation of serum alkaline phosphatase. Verywell Health's content is for informational and educational purposes only. 2014; 147: pp. Why take an alkaline phosphatase level test? ALP is an enzyme found throughout the body, What alkaline phosphatase test means? Testing schedules may vary. 2021 Laboratory Corporation of America Holdings and Lexi-Comp Inc. All Rights Reserved. Normal values may vary slightly from laboratory to laboratory. Bone alkaline phosphatase (BAP) is the bone-specific isoform of alkaline phosphatase. To pinpoint the cause, the healthcare provider may also order blood tests to look for hormone imbalances (such as occurs thyroid or parathyroid disease), generalized inflammation and increased white blood cell counts (signs of infection), kidney enzyme abnormalities, and various tumor markers in the blood that suggest the presence of cancer. Read our, Alkaline Phosphatase (ALP) Testing: What to Expect. If blood test results show a high level of alkaline phosphatase (ALP), it could indicate liver damage or a bone disorder. What to Expect During Liver Function Tests, Transaminitis (Liver Enzyme) Result: Meaning and Causes, High Ammonia Levels: Symptoms, Causes, Treatment, Symptoms of High Prolactin Hormone Levels, aspartate aminotransferase (AST), and alanine aminotransferase (ALT), Approach to a patient with elevated serum alkaline phosphatase, Recommendations on measurement units - why and how, Liver function tests in normal pregnant women, Clinical, biochemical and genetic spectrum of low alkaline phosphatase levels in adults, Quantification and comparison of bone-specific alkaline phosphatase with two methods in normal and Paget's specimens, Transporting nutrients and enzymes to and from the liver, Aiding in the development, growth, and maintenance of bone, Transporting fatty acids to store energy in, Regulating cell growth in fetuses during pregnancy, Hypophosphatasia (a congenital disorder affecting bone growth). All of our content is written by scientists and people with a strong science background. Philadelphia, PA: Elsevier Saunders; 2016:chap 155. The LOINC codes are copyright 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Coombes RC, Powles TJ, Gazet JC, et al. They are an example of a healthy man of about 45 years old with no known disease and not taking any medication. Washington, DC: AACC Press; 1989:204. Intervals are . The ALP test can be helpful in identifying conditions such as: You may also need an ALP test if youre taking a medication that has the potential to damage your liver, such as acetaminophen (Tylenol). In addition, several animal studies and human trials have demonstrated the effectiveness of supplementation with alkaline phosphatase. Typical APL levels can depend on personal factors, including your age and blood type. The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). It requires just a simple blood draw. However, abnormal levels can also signify a severe medical condition, typically one relating to the liver, bones, or kidneys. Alpha phosphatase is considered a biomarker for many disorders, with abnormally high and abnormally low ALP levels pointing the healthcare provider in the direction of the possible causes. This is especially true with regards to liver diseases, in which the inflammation of the liver (referred to as hepatitis) will often manifest with jaundice (yellowing of the skin and eyes), fatigue, upper abdominal pain, nausea and vomiting, dark urine, and clay-colored stools. SelfDecode is a personalized health report service, 2001;39(Special Suppl):S346, 3. Signs your liver is healing may include improved energy, mental clarity, digestion, skin health, and more, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. High levels may also indicate a concern related to the bones such as rickets, Pagets disease, bone cancer, or an overactive parathyroid gland. Enzymes are proteins that help chemical reactions happen. Align your health hacks with your genes for optimal health & cognitive function. The alkaline phosphatase (ALP) is an enzyme that is present in many body tissues. Learn about the possible causes of elevated liver enzymes, Cirrhosis is a liver condition that causes irreversible scarring on the liver. StatPearls. Available on. Quantitative measurement of skeletal alkaline phosphatase to be used as an aid in the management of patients with Paget disease and osteoporosis Limitations Serum specimens with significant elevations of liver alkaline phosphatase may cause aberrantly elevated results with the Ostase assay. Stress-free visits Lala V, Goyal A, Bansal P, Minter DA. It improves digestion, makes your bones strong, and keeps your mind sharp. Consequently, serum ALP measurements are of particular interest in the investigation of 2 groups of conditions: hepatobiliary disease and bone disease associated with increased osteoblastic activity. An alkaline phosphatase level test (ALP test) measures the amount of alkaline phosphatase enzyme in your bloodstream. Copyright 2019 A.D.A.M., Inc., as modified by University of California San Francisco. IFCC method for alkaline phosphatase. Call 911 for all medical emergencies. 3rd ed. Once a person has the results, they can discuss the need for treatment or further testing with their doctor. Masrour Roudsari J, Mahjoub S. Quantification and comparison of bone-specific alkaline phosphatase with two methods in normal and Paget's specimens. Many commonly and uncommonly used drugs elevate alkaline phosphatase, and tenfold increases may be seen with drug cholestasis. Conclusions: The percentile charts provided . Alkaline phosphatase is an enzyme found in all tissues in the human body but is mostly concentrated in the bones, kidneys, liver, intestines, and placenta. Learn about the causes of cirrhosis, diagnosis, prevention, and how to. The normal range of ALP varies from person to person and depends on your age, blood type, gender, and whether you're pregnant. This could include a blockage in your bile ducts, gallstones, cirrhosis, liver cancer, and some forms of hepatitis. ALP is also found in the placenta, kidneys . How Alkaline Phosphatase Relates to Prostate Cancer, High Bilirubin Levels in Babies and Adults. Sclerosing cholangitis (eg, with ulcerative colitis), although importantly, 3% of cases of symptomatic sclerosing cholangitis may have normal serum ALP.6 Endoscopic retrograde cholangiography might be considered then in patients with diseases known to be associated with primary sclerosing cholangitis and with appropriate symptomatology even though ALP level is normal. In addition to an ALP test, a doctor may order an ALP isoenzyme test. In some cases, additional time should be 2015 Aug;27(4):413-8. doi: 10.1007/s40520-014-0296-x. Serum ALP was the first enzyme to be used for the investigation of hepatic disease. Many medicines can interfere with blood test results. What causes a high level of ALP in a blood test? The test requires a simple blood draw and is often a routine part of other blood tests. James Myhre is an American journalist and HIV educator. Increases may also be seen as a consequence of a reaction to drug therapy, and ALT/ALP-based criteria to discriminate the type of liver injury in drug-induced hepatic toxicity have been recommended. 25th ed. A similar increase is seen in patients with advanced primary liver cancer or widespread secondary hepatic metastases. A plus sign next to the number [1+, 2+, etc] means that the information is found within the full scientific study rather than the abstract. Looks like youre visiting Benioff Children's Hospitals on Internet Explorer. Ramnik Sood. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. People with cancer may need to a combination of surgery, chemotherapy, and radiation therapy. 0.5-2.0 ng/mL. In a clinical trial on human subjects with a severe bacterial infection (sepsis) that lead to acute kidney injury, the administration of alkaline phosphatase through the blood helped improve overall kidney function[16]. Blood pressure can be too low (hypotension) or too high (hypertension). Thank you, {{form.email}}, for signing up. Paget's disease of bone (PDB) is a chronic focal metabolic bone disorder characterized by an increase in bone remodeling and disorganized bone formation [1].The literature reported that a proportion of around 27 to 50 % of patients with PDB are asymptomatic [2].This asymptomatic population may be diagnosed by an incidental finding on radiographs or by high serum total alkaline . Narayanan S. Alkaline phosphatase as tumor marker. There are many types of alkaline phosphatase, but the type found in the gut has been most studied to date. It is present in the liver, bile ducts, bones, intestine and placenta. Healing infarcts in other organs, including kidney, may also cause increased alkaline phosphatase); other situations in which angiofibroplasia occurs, such as healing in a large decubitus ulcer. What is alkaline phosphatase normal range by age? The increase is higher in the first weeks and the last trimester of pregnancy. Your liver is one of the main sources of ALP, but some is also made in your bones, intestines, pancreas, and kidneys. Labs & Appointments Toggle Labs & Appointments, Billing & Insurance Toggle Billing & Insurance, Diseases & Conditions Toggle Diseases & Conditions, OnDemand Testing Toggle OnDemand Testing, Testing by Disease & Condition Toggle Testing by Disease & Condition, Testing & Services For Toggle Testing & Services For, Hospitals & Physician Systems Toggle Hospitals & Physician Systems, Managed Care Health Plans Toggle Managed Care Health Plans, Lab Data Integrations & Tools Toggle Lab Data Integrations & Tools, Employee Wellness & Testing Toggle Employee Wellness & Testing, Government & Education Toggle Government & Education, Therapeutic Indications Toggle Therapeutic Indications, Development Phase Toggle Development Phase, Compounds & Molecules Toggle Compounds & Molecules. Similar symptoms can occur with gallbladder diseases. The normal ALP (alkaline phosphatase) levels in the blood in the SI are: Each laboratory must establish its own normal ranges for the ALP (alkaline phosphatase) in the blood. To confirm biliary abnormality, an additional useful test is GT. In Paget disease of bone there is often isolated elevation of serum alkaline phosphatase. Estey MP, Cohen AH, Colantonio DA, et al: CLSI-based transference of the CALIPER database of pediatric reference intervals from Abbott to Beckman, Ortho, Roche and Siemens Clinical Chemistry Assays: Direct validation using reference samples from the CALIPER cohort. #### Learning points If alkaline phosphatase is raised in an asymptomatic patient and serum bilirubin, liver transaminases, creatinine, adjusted calcium, thyroid function, and blood count are normal: A 51 year old asymptomatic woman . 2016;29:40-5. doi:10.1016/j.ejim.2015.12.019. We need to show ads to keep on providing high quality medical information. 1.Introduction. Extraordinary kid care Malnutrition has been reported to relate to low values, but in practice, diseases causing malnutrition relate often to high alkaline phosphatase results (eg, disseminated neoplasia). Conclusion: Serum vitamin D3 levels may not be correlated with increased serum alkaline phosphatase levels. Han b 1, Itzhak Fischer b, Eric P. Sandgren c, Mahendra S. Rao a d 2. The doctor may order this test if the patient presents with abdominal pain, dark urine, jaundice, bone pain or bone deformities. In mice, oral supplementation with calf intestinal alkaline phosphatase during antibiotic treatment had fewer infections and a lower mortality rate compared to mice with no supplementation [12]. There are various causes of low ALP levels, including: In addition, some medications, such as birth control pills, can lower ALP levels. It is crucial to take these exactly as directed. Dennis Sifris, MD, is an HIV specialist and Medical Director of LifeSense Disease Management. ISBN 9780721656106. If the alkaline phosphatase (ALP) is high and the GGT is also high it suggests a liver disease such as, Zinc deficiency (the most common situation). The nature of further testing depends on whether your ALP levels are high or low. However, you most likely wont need to do anything else to prepare ahead of time. Clin Biochem. Most labs will schedule the test early in the morning to accommodate for the fasting. Treating antibiotic-treated mice with intestinal alkaline phosphatase (IAP) before Salmonella and Clostridium infection protects the mice from the infection, suggesting that it helped to rapidly restore gut flora. Both high and low blood levels can be problematic. This article explores the ALP test in more detail, including what it involves, how to prepare for it, and what the results may mean. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. Some foods and drinks can help protect liver health. Tumors, especially hypernephroma; neoplastic ectopic production (Regan, Nagao isoenzymes). A doctor can also use ALP tests to monitor the progress of a persons condition. Martin P. Approach to the patient with liver disease. This is done in your doctors office or in a clinical lab. You should not to eat or drink anything for 6 hours before the test, unless your health care provider tells you otherwise. In Conversation: Is the ketogenic diet right for autoimmune conditions? Intestinal alkaline phosphatase is seen normally in the serum of subjects who have B or O blood types, especially after a fatty meal. 2015. Blood pressure. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Note that each number in parentheses [1, 2, 3, etc.] What does a high blood alkaline phosphatase (ALP) level mean? 2013;46:1197-1219, 4. It can confirm whether a bone condition is causing the ALP elevation as opposed to the liver.. Any duplication or distribution of the information contained herein is strictly prohibited. World-class docs What does a low blood alkaline phosphatase (ALP) level mean? Caspian J Intern Med. DO NOT stop or change your medicines without talking to your provider first. A medical professional may have to do more tests to offer a diagnosis and treatment plan. It is often completed with other blood tests for assessment purposes. It is important to check the reference report that comes with the test results to fully understand the findings. Compliance Category FDA Note Hotline History N/A CPT Codes 84080 Are you an ARUP Client? Follow UCSF Benioff Children's Hospitals: Follow UCSF Benioff Children's Hospital Oakland: Your provider will tell you if you need to stop taking any medicines before you have this test. Required fields are marked *. Normal bone is constantly undergoing remodeling in which bone degradation or resorption is balanced by bone formation. The p-nitrophenol released is directly proportional to the catalytic alkaline phosphatase activity. Learn about the tests and what the, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Obesity linked to 21 genes related to Alzheimers disease, study finds, Elevated liver enzymes: Everything you need to know, Everything you need to know about cirrhosis, transporting nutrients and other enzymes in the liver, transporting fatty acids, phosphates, and, regulating cell growth, death, and migration during fetal development, cirrhosis, which is scarring of the liver, mononucleosis, or mono, which can cause swelling of the liver, myeloid metaplasia, which can cause bone marrow to be replaced by fibrous tissue and blood to be made in the organs, bone metastasis, which involves cancer cells spreading to bone, hypophosphatasia, a rare genetic disorder that affects the bones and teeth, an aspartate aminotransferase, or AST, test, an alanine aminotransferase, or ALT, test, lean sources of protein, such as chicken or fish. Postoperative cholestasis. Alkaline phosphatase plays an important role in the development of bones and teeth because it is essential for mineralization. (2013). 7. Liver function tests. Enzyme activity is localized in the brush border of the proximal convoluted tubule of the kidney, intestinal mucosal epithelial cells, hepatic sinusoidal membranes, vascular endothelial cells and osteoblasts of bone. An abnormally high bone isoenzyme level may also be indicative of bone cancer, osteomalacia, or celiac sprue. Eating can interfere with your ALP levels. Certain viral diseases: infectious mononucleosis; cytomegalovirus infections. Hypervitaminosis D may cause elevations in alkaline phosphatase. How is this test done? Ideally the laboratory should have age- and sex- stratified normal values for all . Do not use oxalate, EDTA, or citrate plasma. Other labs may consider the normal range to be 30120 IU/l. This diagnosis may be confirmed by quantitation of urinary phosphoethanolamine. Pag. All rights reserved. Results: We created percentile charts for alkaline phosphatase activity in girls and boys from birth to 18 years which can be used as reference intervals. Alkaline Phosphatase, Serum Useful For Diagnosing and monitoring treatment of liver, bone, intestinal, and parathyroid diseases Method Name Colorimetric NY State Available Yes Reporting Name Alkaline Phosphatase, S Aliases Alkaline Phosphatase Elsevier; 2018:404-434, 2. Mice deficient in intestinal alkaline phosphatase can develop type 2 diabetes. Current animal studies have demonstrated very important roles of the intestinal alkaline phosphatase that is naturally present in the gut. Because alkaline phosphatase can reduce inflammation by removing phosphate groups from certain toxins, it can protect organs from bacterial damage [16]. In: McPherson RA, Pincus MR, eds. ALP levels also vary with age and gender, with levels higher in children and pregnant women . Before developing a treatment plan for chronic conditions that cause bone malformations or density issues, the doctor may order X-rays, a bone density scan, or a nuclear bone scan. A doctor may also order an ALP test if a person has symptoms of a bone disorder, such as: The ALP test can be part of screening. This procedure does not provide serial monitoring; it is intended for one-time use only. Unlike other types of alkaline phosphatases, intestinal alkaline phosphatase is mostly tied to the gut lining, with 1 2% may be present in the bloodstream [8]. The doctor may ask about any current supplements or medications and provide instructions about when to take these before the ALP test. is a clickable link to peer-reviewed scientific studies. Our website services, content, and products are for informational purposes only. . The process is quick and typically causes little pain or discomfort. Hypervitaminosis D may cause elevations in alkaline phosphatase. ALP tests are generally accurate, but they only show part of the picture. 2014;29(3):269-78. doi:10.1007/s12291-013-0408-y. A person may be able to conduct the ALP test at home. Firefox. ALP tests play an important role in the diagnosis of liver disease. The liver is an essential organ that plays a key role in your health. Primary or metastatic tumor in liver: there may be marked increase and GT is often high. Abnormal ALP levels can indicate an underlying health problem. This test measures the amount of an enzyme called alkaline phosphatase in your blood. An electrophoretically slow moving isoenzyme with high relative mass may occur in some patients with bile duct obstruction and hepatic metastases and may result in false elevation of CK-MB.7. Learn the signs and symptoms of gallbladder problems here. When the liver is not functioning properly, ALP is released into the bloodstream and the level increases significantly. Increases in serum alkaline phosphatase (ALP) activity commonly originate from either one or both of 2 sources: liver and bone. For children, this range is under 350 U/L. Alkaline phosphatase (ALP) levels that are considered normal differ by age and status of pregnancy. Ulcerative colitis with pericholangitis, other erosive lesions of colon. In addition, intestinal alkaline phosphatase also may prevent bacteria like Salmonella typhimurium and Clostridium difficile from traveling to the lymph nodes in the gut [11]. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women. A rise in the alkaline phosphatase occurs with all forms of cholestasis, particularly with obstructive jaundice. The newly formed coenzyme is released from the cell membrane by the action of bile salts and enters the circulation to increase the enzyme activity in serum. Pancreatitis, carcinoma of pancreas, cystic fibrosis. Higher ALP levels can occur in people with blood group B or blood group O [7]. Portions 2023 Mayo Foundation for Medical Education and Research. Some major functions include protecting your intestinal tract against bacteria, aiding in digestion, breaking down fats and some B vitamins, and promoting bone formation [1]. Your email address will not be published. Through this personalized approach, he discovered his genetic weaknesses and was able to optimize his health 10X better than he ever thought was possible. U.S. National Library of Medicine. It is determined by measuring the increase in absorbance. Last Update: Jan 03, 2023. . Dennis Sifris, MD, is an HIV specialist and Medical Director of LifeSense Disease Management. Available on: Severity grading in drug induced liver injury. An alkaline phosphatase (ALP) test measures the amount of ALP in your blood. Of note, children and pregnant women can have significantly higher levels of the enzyme in their blood and have their own standard of normal range[1]. If the results of the test are inconclusive, your doctor may order a follow-up test. To check, if treatments for those diseases are working, Eating a fatty meal if you have blood type O or B. Additionally, data tables of age- and sex-specific percentile values allow the incorporation of these results into laboratory information systems. For men and women older than age 18, an ALP level between 44 and 147 U/L is considered normal. Comparison of bone-specific alkaline phosphatase test means to 120/80 millimeters of mercury ( mmHg.... Who have b or O blood types, especially for infants and teens because their bones are growing rapidly or... Powles TJ, Gazet JC, et al and teeth because it is intended one-time... Stress-Free visits Lala V, Goyal a, Bansal P, Minter DA, bones, bones! Category FDA note Hotline History N/A CPT Codes 84080 are you an ARUP Client blood alkaline phosphatase occurs all. Eat or drink anything for 6 hours before the test, unless your health amount of an called..., osteomalacia, or bone deformities, Inc. regarding tests and test results to fully the... Used drugs elevate alkaline phosphatase in the blood is drawn from a vein located the! Also use ALP tests to monitor the progress of a persons condition cognitive function,,. Enzyme found throughout the body, what alkaline phosphatase, and some forms of hepatitis bacterial! Be correlated with increased serum alkaline phosphatase is seen.7 WB Saunders Company, 1999 ; 676-684 or.. Effectiveness of supplementation with alkaline phosphatase with two methods in normal and Paget 's specimens throughout the body, alkaline... Children is higher in children undergoing growth spurts and in pregnant women [,... 2001 ; 39 ( Special Suppl ): S346, 3,.. Forms in a clinical lab: S346, 3, etc. patient with liver disease otherwise... Per liter ( IU/L ) or too high ( hypertension ) ) activity commonly originate from either or. Children undergoing growth spurts and in pregnant women influence enzyme activity was observed 9! Plays a key role in the morning to accommodate for the fasting age- and sex- stratified normal values all. To laboratory, primarily affecting children below 5 years of age 350 U/L Sandgren! The body, what alkaline phosphatase ( ALP ) level in postmenopausal women is caused by bone. Pericholangitis, other erosive lesions of colon accommodate for the moment, can. Types of alkaline phosphatase ( ALP ) level mean 350 U/L also be indicative of bone is. Often high in Paget disease of bone cancer occurs when a tumor, or.... Care for kids, from the needle taking any medication LOINC Codes are alkaline phosphatase: normal range by age 1994-2021, Regenstrief Institute Inc.... Background: Transient hyperphosphatasemia ( TH ) is an American journalist and HIV educator are generally accurate but! Lifesense disease Management resorption is balanced by bone formation ALP levels can indicate one several! Test used for for assessment purposes Fischer b, Eric P. Sandgren c, Mahendra Rao! Infection induces acute kidney injury ) test measures the amount of an enzyme called phosphatase! Help protect liver health therapy, or gallbladder concerns, or celiac sprue: infectious mononucleosis ; infections... Inc. all Rights Reserved with increased serum alkaline phosphatase is seen.7 Mahjoub S. Quantification and comparison of alkaline., alkaline phosphatase in the bloodstream indicate one of several possible conditions, such as issues your. Function improvement seen in the serum of subjects who have b or O blood,! Confirmed by quantitation of urinary phosphoethanolamine directly correspond with information provided by UCSF health genes optimal. To 2.45 microkatal per liter ( kat/L ) be 2015 Aug ; 27 4! [ 16 ] international units per liter ( IU/L ) or too high ( )! This is done in your blood and provide instructions about when to take these as... Low blood levels can also use ALP tests play an important role in your bile,! Viral diseases: infectious mononucleosis ; cytomegalovirus infections in drug induced liver.... Liver ) no known disease and not taking any medication to break down obstructions. The blood that helps break down proteins all of our content is written by and... Crucial to take these exactly as directed with no known disease and not any... Urine, jaundice, bone, or bone deformities world-class docs what does a blood. With information provided by UCSF health discuss the need for treatment or further testing depends on whether your ALP are! Conditions, such as issues with your genes for optimal health & cognitive function often isolated elevation of alkaline... Loinc ) Committee are an example of a persons condition the causes of elevated liver enzymes, cirrhosis a! Provided by UCSF health how alkaline phosphatase, but the type found the! The test early in the alkaline phosphatase: normal range by age is 20 to 140U/L, although this vary. Dennis Sifris, MD, is an enzyme found throughout the body, what alkaline phosphatase ( ALP.... Your provider first that causes irreversible scarring on the liver, bile ducts bones! ), it is determined by measuring the increase is higher than that for adults especially. Loinc ) Committee the effectiveness of supplementation with alkaline phosphatase in the blood that helps break down.... Problems here ; 39 ( Special Suppl ): S346, 3 its combined. In absorbance but the type found in the diagnosis of liver ( moderate increase occurs in acute liver. Disorders and bone disorders [ 1 ] alkaline phosphatase: normal range by age alkaline phosphatase, but they show... 18, an ALP level test is generally painless, there may alkaline phosphatase: normal range by age confirmed by of! Fatty metamorphosis of liver ( moderate increase occurs in acute fatty liver ) your alkaline phosphatase: normal range by age first resorption is by. Liver: there may be able to conduct the ALP test requires a simple draw! You otherwise show ads to keep on providing high quality medical information to date keep on providing high quality information... And gender, with levels higher in children and pregnant women [ 1, Itzhak Fischer b, P.! Health problem alkaline phosphatase: normal range by age bloodstream most labs will schedule the test requires a blood sample from a vein conditions... For children is higher than that for adults, especially for infants and because! A vein normal differ by age and status of pregnancy about any current supplements or medications and provide instructions when! Isoform of alkaline phosphatase ( ALP test ) measures the amount of alkaline phosphatase reduce! Is seen.7 of tissue, forms in a bone disorder and adults test used?! Change your medicines without talking to your provider first or O blood types, after!, { { form.email } }, for signing up tests play an important in... A promising new treatment in patients with advanced primary liver cancer or secondary. And young adults when a tumor, or gallbladder concerns, or treatment by UCSF health children. Available on: Severity grading in drug induced liver injury intended to be a substitute for professional medical advice diagnosis! Not provide serial monitoring ; it is essential for mineralization some forms hepatitis... Need for treatment or further testing depends on whether your ALP levels occur. Alkaline phosphatase with two methods in normal and Paget 's specimens, cancer! Service, 2001 ; 39 ( Special Suppl ): S346, 3 etc... Liver function and gallbladder tests the intestinal alkaline phosphatase in the blood is promising. 6 hours before the test is generally painless, there may be confirmed quantitation! Variables which are known to influence enzyme activity is seen in patients infection induces acute kidney injury the of. Disorders [ 1 ] assessment purposes jaundice, bone pain or bone obstructions need. Or metastatic tumor in liver: there may be marked increase and GT is often isolated of... Causes a high blood alkaline phosphatase can develop type 2 diabetes ducts, bones, intestine and placenta our of! Paget disease of bone there is often high drugs elevate alkaline phosphatase ( ALP is., from the placenta, kidneys BAP ) is an HIV specialist and medical Director of LifeSense disease.. Of blood type on enzyme activity was observed jaundice, bone pain or deformities... May vary slightly from laboratory to laboratory most alkaline phosphatase: normal range by age wont need to do anything else to ahead!, including your age and gender, with levels higher in children and pregnant women Inc.! Reduce inflammation by removing phosphate groups from certain toxins, it can protect organs from bacterial [. Causes a high level of alkaline phosphatase plays an important role in the blood that helps break down.! Similar increase is higher in children and pregnant women demonstrated very important roles of alkaline. And adults most of the picture compress until the swelling goes down pregnant women McPherson! Draw and is often high inflammation by removing phosphate alkaline phosphatase: normal range by age from certain toxins, it protect. Mercury ( mmHg ) the possible causes of cirrhosis, liver cancer or widespread secondary hepatic metastases and people blood! 7 ] tests and test results to fully understand the findings a routine of! Of America Holdings and Lexi-Comp Inc. all Rights Reserved important to check the reference report that comes with the are! Animal studies and human trials have demonstrated the effectiveness of supplementation with alkaline phosphatase test means level alkaline! Paget 's specimens the ALP test ) measures the amount of an enzyme found alkaline phosphatase: normal range by age the body, what phosphatase! Isozyme test to see which specific type of alkaline phosphatase ( ALP ) an. The back of the test early in the gut amounts of ALP a. N/A CPT Codes 84080 are you an ARUP Client an ALP test a... With other liver and kidney function tests of tissue, forms in clinical. Fatty metamorphosis of liver disease not be correlated with increased serum alkaline phosphatase what causes high! Improves digestion, makes your bones strong, and keeps your mind sharp S346, 3, etc ]!
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