(No judgment if you didnt see that section: I know its a very long article and I expect most people are looking for a quick or specific answer and dont actually read the whole thing ?.) For instance, some MLs are best tolerated when orally ingested, which meant that a pill form of that particular compound was developed; but moxidectin was just the opposite. Im now looking for something else to use, but want to pick something safe for my girl (and its easier to keep them on the same thing if possible). And safe travels to you and Lola in the future. All dogs treated with SIMPARICA TRIO were negative for D. immitis antigen and blood microfilariae at study completion on day 330. On the downside, its efficacy only lasts for about a day. Isoxazolines like NexGard, Simparica and Bravecto are very important for tick prevention and appear safe to use. I read that you you used this combination with success. Simparica TRIOse administra va oral una vez al mes, a una dosis de 1.2 mg de sarolaner/kg de peso corporal; . What do you think about Frontline Gold? I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. Last year I used Frontline Plus with no issues. Frontline Plus targets four kinds of ticks, fleas (including eggs and larvae), lice, and mites that cause sarcoptic mange. However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. Hi! Thank you, and hello to Nola and Otis! (One such knockoff, Pet Armor Plus, is even available at Walmart.). I say this as she is running around the room l barking and trying to dig up the coachyep, just about nap time, That is excellent news, and Im so glad to hear it! Unless youre, say, an expat living in China, you can definitely find a better option. I gave a mini aussie and a minnie aussie/border collie mix. I have a 20 month old smith Border Collie who is heterozygous for the MDR1 gene. If you havent yet contacted either organization, the numbers to call are 1-800-422-9874 (according to the Seresto product label) and 1-800-858-7378 for the National Pesticide Information Center (according to the FDA.gov website). Our dogs deserve the best. Hypersensitivity reactions may occur in some dogs when ProHeart is administered alone . So glad you found this useful! As one holistic veterinarian explains: The Vectra 3D can have side effects which include extreme restlessness and jitteriness, described as anxiety or manic behavior. We have two collies, Dash (8 yr old male) and Roxie (2.5 yr old female). However, it is strong and can cause a skin reaction. Where can I get them tested for MDR1 resistance. A dog on Heartgard may heaven forbid, but dogs can be gross eat the feces of an animal who was given an Ivermectin-based medication. As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! They were extremely helpful people. She has shown personality signs of that condition ever since, which are controlled by a dose of a quarter pill of trazadone as needed. I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. Dosage is at .91mg/lb (2mg/kg) Simparica should only be administered to dogs 6 months of age and older. I like the idea of trying a coller, but it really needs to work because lyme is a problem where we live. Simparica is safe for Australian Shepherds and offers a number of benefits, including: -It is fast-acting and begins to kill fleas within hours. Simparica Trio proven to block the pathogen that causes Lyme disease by killing deer ticks . Thank you for this thorough and thoughtful work, Emily! Though all of these medicines had previously been approved by FDA scientists, now data received by the agency indicates that some animals receiving Bravecto, Nexgard, or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.. And its possible for dogs and humans both to have allergies even to natural essential oils. Some remain safe, others should be avoided. It makes me nervous since I have seen/read plenty of negative things about bravecto and Im also worried to combine bravecto with interceptor. Parastar Plus is not something Ive personally used, but it should be safe as one of its active ingredients is Fipronil (which is in Frontline) and the other active ingredient, Cyphenothrin, is in the same family of drugs as Permethrin. I found this after hearing about the Seresto issues and how they werent accurately reporting data. Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Took that collar right off her. Simparica Trio 11.1-22 lbs. I doubt it as he was on leash and Im always watching him. My personal vet is knowledgeable of the MDR1 gene mutation (now also referred to as the ABCB1 mutation), and he recommended Interceptor to me for my mutant/normal Collies. Sounds like shes still going strong at her advanced age, and thats awesome. Happy to help! . In the United States, DEC (diethylcarbamazine) was sold as Filaribits or Nemacide, but they no longer appear to be on the market. Great summary! Safe in avermectin-sensitive collies and dogs with the MDR1 gene; Simparica Trio is a tasty monthly chew that provides protection against the biggest threats facing our dogs; fleas, ticks, intestinal worms and deadly heartw. Hes just a puppy himself and was already started on Interceptor and Credelio. Doses used for heartworm prevention are safe to use in these breeds of dogs. I quoted a specific veterinarian who mentioned why she never diagnoses Nexgard and Heartgard together. I have never even heard of the latter and do not believe they exist in Canada. (There are 13 other at-risk breeds including Border Collies, Australian Shepherds, German Shepherds, Shetland Sheepdogs, and Old English Sheepdogs, plus herding breed mixes. . If it is, it could possibly double as heartworm prevention, although I would highly recommend getting more frequent heartworm tests done (perhaps 3-4 times per year, or as often as your vet recommends) to make sure no mosquitoes managed to infect your dog with heartworms. Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. Product Description. These three are listed as a new group of drugs called Isoxazolines, and are neurotoxins. Background: The efficacy and safety of a novel isoxazoline compound, sarolaner (Simparica , Zoetis) and spinosad (Comfortis , Elanco) as a positive control were evaluated for the treatment and control of natural flea infestations on dogs in two randomised, blinded, multi-centric clinical trials conducted in 11 veterinary clinics in northeastern and southeastern states of Australia. I did write this article a couple of years ago; but I have updated it several times since most recently after information came out about some fatal reactions to Seresto collars. Thank you. I do remember her cowering and rubbing her back against her crate after we administered anything topical! . Your sense of humor is enlightening also. . Because I am only one person, the medication is relatively new, and it has active ingredients that are the same as more well-known medications that have been known to cause issues for many dogs, I didnt feel that I could give it an entirely glowing recommendation. The login page will open in a new tab. They said Frontline Plus doesnt really work anymore like it used too. If youre hoping for a quick, easy skim and just want to know which pest protections are considered safe, Ill list those first under each heading, followed by the use with caution category, and finally the not safe options. If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. (There are other places, but none more affordable that Ive found.) My Vet told me Trifexis was safe to give them. Hi Vicki, But Ive given it a caution designation as it should not be given in combination with heartworm meds and is not safe for dogs who are at risk for seizures. Safety has not been evaluated in pregnant, breeding or lactating dogs. HEARTGARD Plus real-beef chews are the delicious, #1 vet-recommended heartworm disease preventive - and pair perfectly with #1 vet-recommended NexGard (afoxolaner) chews. The collar releases no odor or residue, comes with a quick release catch to prevent accidental choking, and even has safety reflectors. Roxie has never been tested, but she is Dashs niece so probably also mutant/normal if I were to guess. A couple people claimed that the trick to getting them to work well is to use a slicker brush to part the fur of the mane, to ensure the collar is close to the skin for best effect. If youre concerned about a possible hormonal imbalance being triggered by Effifax, it might be worth looking into an alternate flea control product that does not contain Fipronil. Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. Interceptor, which comes in a monthly chewable form, has been specifically tested and approved for dogs with MDR1. I personally prefer something gentler as many Collies can have sensitive skin, but it really depends on the dog. Thank you for all your research and article!! I dont use Credelio anymore and just stick to Frontline Plus combined with a weekly application of Natural Chemistry flea and tick spray. I had never heard of Dimmitrol before, but I did some research after reading your comment. Frontline Plus is milder than Frontline Gold, which I wouldnt recommend for the same reason that I dont like recommending Advantix theyre too strong and have a tendency to cause skin reactions. Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. 5,10 That's two tasty chews to double your dog's dosing delight each month. The product insert states Do not use this product on debilitated, aged, medicated, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products., If you live in a seasonal region where you actually experience winter complete with freezing temperatures and snow, and your pets have been on regular pest preventive products, you can give them a break from chemicals for a few months while the insects are dormant. Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. Apparently, it affects certain cats with a certain gene. for, I think its brown ticks. It seems unlikely for that much time to elapse before a reaction, but I would definitely consult with a veterinarian. After a single administration of 5 times the maximum recommended dose to this sensitive dog breed, transient Simparica TRIO was approved by the U.S. Food and Drug Administration's (FDA) Center for Veterinary Medicine in March 2020. Nexgard and Simparica. Feel free to come back here and share any other information you learn or just to give a puppy growth update. Simparica Trio is an all-in-one monthly chewable treatment for dogs. Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. The graphic right at the top of this page might be helpful for you; it lists the drugs that are potentially dangerous for MDR1 dogs. I tried to review a variety of the most well-known parasite protection products out there, but if I left out any you are curious about, leave a comment below! WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. Get new post updates in monthly email newsletters. Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! Simparica Trio Chewable Tablets for Dogs works to prevent heartworms as well as treat lone star ticks, black-legged ticks, Gulf Coast ticks, American dog ticks, brown dog ticks, fleas, roundworms, and adult hookworms. We sometimes see a Smooth Collie named Frank at our local dog park, and Ive been pretty impressed with him. But it doesnt hurt mammals. We will get her in about 3 weeks. The MDR1 mutation is most commonly seen in herding breeds. If an MDR1-affected dog were to be treated for mange, that would involve higher dosages and could cause adverse reactions. Matching game, word search puzzle, and hangman also available. ? I gave her Simparica 5 weeks ago for the first time. Sarolaner is an . Thank you for your article. Unfortunately, it seems most people who lost their dogs to Seresto collars simply did not make the connection until it was too late. I have 7 collies and I am reluctant to put them on anything thats not natural , we did get a kitten and found a flea so looking for something to treat all as a precautionary for a month as we are in winter season in Northern Ontario Canada. On the down side, it does not cover any ticks. One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. Study free flashcards about heartworm extra note created by Dkamplain to improve your grades. Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. From the time that the collar went on the market in 2012 until 2020, the EPA (Environmental Protection Agency) received 1,698 reports of deceased pets. As such, Prinovoxs 2 active ingredients are Imidacloprid (for fleas, but it doesnt target ticks) and Moxidectin (for heartworm, roundworm, and lungworm). Thank you for writing this article. Oh no! For anyone who prefers to use organic instead of chemical products or would like a repellent in addition to what you are already using, this is the flea and tick spray for you! I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. Class A DO NOT use these drugs in dogs with the MDR1 Gene Defect Ivermectine substances "Anti parasites": (Diapec, Ecomectin, Equimax, Eqvalan, Ivomec, Noromectin, Paramectin, Qualimec, Sumex, Virbamec) Doramectine substances "Anti parasites": (Dectomax ) 2022 Collie Chatter. The active ingredients in Hartz look pretty harsh, so Id be concerned with skin irritation in the ear canal. In effect, its like a canine-safe version of Ibuprofen, and it really did help her. (CAS 112945-52-5) Oral Acute LD50 Rat > 22500 mg/kg Skin corrosion/irritation Prolonged skin contact may cause temporary irritation. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. PARSIPPANY, N.J. - January 04, 2022 - Zoetis today announced that the U.S. Food and Drug Administration (FDA) has approved a new label indication for Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets) for the prevention of Borrelia burgdorferi infections as a direct result of . Border collie females with sarcoptic mange mutant/normal if i were to guess a!, you can definitely find a better option group of drugs called,... Old MAS/Aussie who is MDR1 +/+ and i have a sensitivity to a certain substance should... Odor or residue, comes with a weekly application of Natural Chemistry flea and tick spray oral LD50. Drugs that may be dangerous for dogs with MDR1 have had no issues still going strong at her age. To a certain substance and should always be monitored for reactions after a new group drugs. And safe travels to you and Lola in the future kinds of ticks, fleas ( including eggs and ). Smooth collie named Frank at our local dog park, and thats awesome it most... 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